The proposed network comprises Belgian and foreign research teams active in the field of neuro-immuno gastroenterology. Immune activation is an important mechanism of disease in overt inflammatory diseases of the gastrointestinal tract, such as inflammatory bowel disease (IBD). The partners involved in this network however have demonstrated that also clinical conditions such as ileus, ischemia / reperfusion and functional bowel disorders (functional dyspepsia, irritable bowel syndrome) are immune-mediated inflammatory diseases in which mucosal barrier dysfunction and increased exposure to luminal antigens may play an important role. However the exact mechanisms leading to immune activation and subsequent abnormal gastrointestinal function remain largely unclear and will be further investigated in the current project. More specifically, the partners will investigate which inflammatory triggers are involved in immune-mediated gastrointestinal disorders, how neurotransmitters and hormones modulate the immune system and which mechanisms are involved in neuromuscular dysfunction and pain perception induced by immune activation. The findings of the current project may improve our understanding of the mechanisms leading to immune activation and subsequent gastrointestinal motility changes and increased visceral hypersensitivity. This could lead to more efficient therapy, better pain and symptom control in patients and therefore an improvement of the quality of life of patients.